Vortioxetine
Antidepressant — multimodal
Indications
Depression
Adult dose
Start 10 mg OD; usual 5–20 mg OD.
Common side effects
NauseaDiarrhoeaDizzinessPruritus
Serious side effects
HyponatraemiaSerotonin syndromeBleeding
Contraindications
MAOI within 14 days
Monitoring
- Mood/suicidality early
Notable interactions
- Strong CYP2D6 inhibitors (paroxetine, fluoxetine, bupropion) — reduce dose
- MAOIs
- Other serotonergic
Curated reference based on BNF, Maudsley Prescribing Guidelines and NICE. Verify against current BNF and local guidelines before prescribing.