Lisdexamfetamine
Stimulant — ADHD
Indications
ADHD (children ≥6 yrs and adults, often after methylphenidate)
Adult dose
Start 30 mg morning, titrate to 50–70 mg/day.
Paediatric dose
≥6 yrs: 30 mg morning, max 70 mg/day.
Common side effects
Reduced appetite/weight lossInsomniaDry mouthHeadacheAnxiety
Serious side effects
Cardiovascular eventsPsychotic symptomsAggressionGrowth retardationDependence/misuseSerotonin syndrome with serotonergics
Contraindications
As methylphenidate
Monitoring
- As methylphenidate
Notable interactions
- MAOIs (within 14 days) — hypertensive crisis
- Serotonergics
- Acidifying agents reduce absorption
Curated reference based on BNF, Maudsley Prescribing Guidelines and NICE. Verify against current BNF and local guidelines before prescribing.